Atf2<tm2Nicj> Targeted Allele Detail MGI Mouse (MGI:3720851)

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Atf2^tm2Nicj
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Atf2^tm2Nicj
Name:	activating transcription factor 2; targeted mutation 2, Nic Jones
MGI ID:	MGI:3720851
Synonyms:	Atf2^AA
Gene:	Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
Alliance:	Atf2^tm2Nicj page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:123909
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Nucleotide substitutions
		Mutation details: A targeting vector was designed to mutate Thr51 and Thr53 into alanines in exon 4 (T51A, T53A). A floxed neo was inserted into intron 3. (J:123909)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Atf2 Mutation:	89 strains or lines available

References

Original:	J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
All:	2 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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